In Greek mythology, Pandora (meaning, all gifted and giving) was the first woman on earth created by Zeus, (she was not created to plague man as stated in some texts). The Gods bestowed on her such gifts as natural beauty, charm and natural curiosity that all spiritual beings have. The opening of the box containing all the troubles and diseases of the world is a metaphor for becoming identified with the physical experience of living in the earth plane (opening the door to the world of physical sensation and sensory input as a source of knowing), only hope was left in the box. There is still hope left - but not very much.
The Greek mystery schools were available to anyone who was spiritually developed enough to understand the secret message in mythology.